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Solid Tumor Profiling from Tissue
for Targeted Therapy Selection

OncoGxSelect™ is a NGS panel that
aligns with well-established guidelines

OncoGxOne™ provides clinicians with
a comprehensive option for their tumor profiling needs

Solid Tumor Profiling from Tissue
for Targeted Therapy Selection

OncoGxSelect™ is a NGS panel that
aligns with well-established guidelines

OncoGxOne™ provides clinicians
with a comprehensive option for
their tumor profiling needs

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oncogxselect Solid Tumor Profiling

OncoGxSelect™ analyzes a patient’s tumor for genetic mutations frequently found in select cancers. This test utilizes Next Generation Sequencing (NGS) technology to detect alterations in 12 known oncogenes and is aligned with well-established molecular testing guidelines. Actionable results help guide therapeutic decisions related to targeted cancer therapy. Additionally, OncoGxSelect™ detects all types of mutations (SNV, gene fusion, Indel, CNV) with a high degree of accuracy.

View OncoGxOne™ Comprehensive Panel

Target Onco Genes

ALK BRAF EGFR ERBB2 KIT KRAS
MAP2K1 MET NRAS PIK3CA RET ROS1

Relevant Solid Tumor Types

Gene Variant Type Responsive Resistant
ALK EML4-ALK Fusion Crizotinib, Ceritinib, Alectinib Gefitinib, Erlotinib, Afatinib
KIF5B-ALK
TFG-ALK
T1151_L1152insT Indel Crizotinib
L1152R SNV
C1156Y
F1174L
L1196M Brigatinib
G1202R
S1206Y
G1269A
BRAF V600E SNV Vemurafenib, Dabrafenib, Dabrafenib+Trametinib
ERBB2 A775_G776insYVMA Indel Trastuzumab, Afatinib
G776_777insVC
Exon20_ins
G776L SNV Trastuzumab
EGFR G719A SNV Gefitinib, Erlotinib
G719C
G719S
D761Y Gefitinib, Erlotinib
K745_A750del Indel Gefitinib, Erlotinib, Afatinib
E746_A750del
E746_A750delELREA
E746_S752delinsA
L747_S752del
Exon19_del
A763_Y764insFQEA
D770_N771insSVD Gefitinib, Erlotinib
Exon20_ins
T790M SNV Osimertinib
C797S Osimertinib
L858R Gefitinib, Erlotinib, Afatinib
L861Q Gefitinib, Erlotinib
KRAS G12A SNV Gefitinib, Erlotinib
G12C
G12D
G12R
G12S
G12V
G13A
G13C
G13D
G13R
G13S
G13V
Q61H
Q61K
Q61L
Q61R
MET Amplification CNV Crizotinib
Exon14_skipping Fusion
RET NCOA4-RET Fusion Cabozantinib
CCDC6-RET
KIF5B-RET
ROS1 CD74-ROS1 Fusion Crizotinib
GOPC-ROS1
SLC34A2-ROS1
EZR-ROS1
SDC4-ROS1
TPM3-ROS1
LRIG3-ROS1
Gene Variant Type Responsive Resistant
BRAF V600E SNV Dabrafenib+Trametinib, Vemurafenib+Cobimetinib
V600K Dabrafenib+Trametinib, Vemurafenib+Cobimetinib, Vemurafenib, Dabrafenib
KIT Amplification CNV Imatinib
W557R SNV
V559A
V560D
L576P
K642E
MAP2K1 C121S SNV Trametinib
Gene Variant Type Responsive Resistant
ALK STRN-ALK Fusion Crizotinib, Ceritinib
EML4-ALK
BRAF V600E SNV Vemurafenib, Dabrafenib
EGFR Amplification CNV Vandetanib
MET Amplification CNV Cabozantinib
RET NCOA4-RET Fusion Vandetanib, Cabozantinib
CCDC6-RET
C634W SNV Vandetanib
C634R
C634Y
M918T
Gene Variant Type Responsive Resistant
N/A WT Cetuximab, Panitumumab
BRAF V600E SNV Cetuximab, Panitumumab
KRAS G12A SNV Cetuximab, Panitumumab
G12C
G12D
G12R
G12S
G12V
G13A
G13C
G13D
G13R
G13S
G13V
Q61H
Q61K
Q61L
Q61R
K117N
A146P
A146T
A146V
NRAS G12A SNV Cetuximab, Panitumumab
G12C
G12D
G12R
G12S
G12V
G13A
G13C
G13D
G13R
G13S
G13V
Q61H
Q61K
Q61L
Q61R
Gene Variant Type Responsive Resistant
ERBB2 Amplification CNV Trastuzumab,  Trastuzumab+Chemotherapy
EGFR Overexpression Nimotuzumab
KIT WT Regorafenib Imatinib
L576P SNV Imatinib
W557R
V559A
K642E
V560del Indel
PDGFRA D842V SNV Dasatinib Imatinib
Gene Variant Type Responsive Resistant
ERBB2 Amplification CNV Trastuzumab,  Trastuzumab+Chemotherapy
PIK3CA H1047R SNV Temsirolimus, Everolimus
oncogxone-sm Solid Tumor Profiling

OncoGxOne™ is a comprehensive Next Generation Sequencing (NGS) based test that profiles tumors for targeted therapy selection and chemotherapeutic tolerance.

  • 64 gene panel: 56 cancer related genes and 8 genes related to pharmacogenomics.
  • Comprehensive coverage of clinically actionable alterations found in multiple cancer types, covering all exons, 5’ and 3’ UTRs, and select introns known to harbor breakpoints.
  • Detects SNV, indel, CNV and gene fusion
Gene Therapeutic Area
ABL1 Chronic Myeloid Leukemia
AKT1 Breast Cancer
Colorectal Cancer
Non-Small Cell Lung Cancer
ALK Anaplastic Large Cell Lymphoma
Inflammatory Myofibroblastic Tumor
Neuroblastoma
Non-Small Cell Lung Cancer
Rhabdomyosarcoma
ATM Diffuse Large B-Cell Lymphoma
Mantle Cell Lymphoma
Chronic Lymphocytic Leukemia
AURKA Colorectal Cancer
BCL2 Lymphoma
BCL6 Lymphoma
BCR Chronic Myeloid Leukemia
BRAF Colorectal Cancer
Gastrointestinal Stromal Tumor
Glioma
Melanoma
Non-Small Cell Lung Cancer
Ovarian Cancer
Thyroid Cancer
BRCA1 Breast Cancer
Ovarian Cancer
BRCA2 Breast Cancer
 Ovarian Cancer
CCND1 Breast Cancer
Gene Therapeutic Area
CCNE1 Ovarian Cancer
CDK4 Breast Cancer
Liposarcoma
CEBPA Acute Myeloid Leukemia
CRLF2 Acute Lymphoblastic Leukemia
CTNNB1 Melanoma
DDR2 Non-Small Cell Lung Cancer
DNMT3A Acute Myeloid Leukemia
Myelodysplastic Syndromes
EGFR Colorectal Cancer
Glioblastoma
Head and Neck Squamous Cell Carcinoma
Non-Small Cell Lung Cancer
ERBB2 Breast Cancer
Gastric Cancer
Non-Small Cell Lung Cancer
ESR1 Breast Cancer
ETV6 Myelodysplastic Syndromes
Prostate Cancer
FGFR1 Breast Cancer
Non-Small Cell Lung Cancer
FGFR2 Breast Cancer
FGFR3 Bladder Cancer
Glioblastoma
FLT3 Acute Lymphoblastic Leukemia
Acute Myeloid Leukemia
GNA11 Melanoma
GNAQ Melanoma
Gene Therapeutic Area
HRAS Thyroid Cancer
IDH1 Acute Myeloid Leukemia
Glioma
IDH2 Acute Myeloid Leukemia
Glioma
JAK1 Acute Lymphoblastic Leukemia
Myeloproliferative Neoplasms
JAK2 Acute Lymphoblastic Leukemia
Myeloproliferative Neoplasms
KIT Acute Myeloid Leukemia
Gastrointestinal Stromal Tumor
Melanoma
Non-Small Cell Lung Cancer
Thymic Carcinoma
KMT2A Acute Myeloid Leukemia
KRAS Colorectal Cancer
Non-Small Cell Lung Cancer
Ovarian Cancer
Thyroid Cancer
MAP2K1 Melanoma
Non-Small Cell Lung Cancer
MET Non-Small Cell Lung Cancer
MPL Haematopoietic Neoplasms
MYC Small Cell Lung Cancer
NF1 Melanoma
Myelodysplastic Syndromes
NPM1 Anaplastic Large Cell Lymphoma
Acute Myeloid Leukemia
Gene Therapeutic Area
NRAS Colorectal Cancer
Melanoma
Non-Small Cell Lung Cancer
Thyroid Cancer
PDGFRA Gastrointestinal Stromal Tumor
PDGFRB Myeloid Neoplasms
PIK3CA Breast Cancer
Colorectal Cancer
Non-Small Cell Lung Cancer
Ovarian Cancer
Squamous Cell Cervical Cancer
PTCH1 Gastric Cancer
Medulloblastoma
PTEN Breast Cancer
Colorectal Cancer
Non-Small Cell Lung Cancer
Ovarian Cancer
RARA Acute Myeloid Leukemia
RET Non-Small Cell Lung Cancer
Thyroid Cancer
ROS1 Non-Small Cell Lung Cancer
RUNX1 Acute Myeloid Leukemia
Myelodysplastic Syndromes
SMO Basal Cell Carcinoma
Medulloblastoma
TP53 Cancer
Myelodysplastic Syndromes
TSC1 Bladder Cancer

Pharmacogenomics Related Genes

CYP2C8 CYP2D6 DPYD MTHFR TPMT TYMS UGT1A1 XRCC1
Ado-trastuzumab emtansine (Kadcyla) Goserelin (Zoladex) Regorafenib (Stivarga)
Afatinib (Gilotrif) Imatinib (Gleevec) Ruxolitinib (Jakafi)
Alectinib (Alecensa) Ipilimumab (Yervoy) Sirolimus (Rapamune)
Anastrozole (Arimidex) Lapatinib (Tykerb) Sorafenib (Nexavar)
Bosutinib (Bosulif) Lenvatinib (Lenvima) Sunitinib (Sutent)
Cabozantinib (Cometriq) Letrozole (Femara) Tamoxifen (Soltamox; Nolvadex)
Ceritinib (Zykadia) Leuprolide (Lupron; Eligard) Temsirolimus (Torisel)
Cetuximab (Erbitux) Nilotinib (Tasigna) Tofacitinib (Xeljanz)
Cobimetinib (Cotellic) Nintedanib (OFEV) Toremifene (Fareston)
Crizotinib (Xalkori) Nivolumab (Opdivo) Trametinib (Mekinist)
Dabrafenib (Tafinlar) Olaparib (Lynparza) Trastuzumab (Herceptin)
Dasatinib (Sprycel) Osimertinib (Tagrisso) Tretinoin; ATRA (Vesanoid)
Erlotinib (Tarceva) Palbociclib (Ibrance) Vandetanib (Caprelsa)
Everolimus (Zortress; Affinitor) Panitumumab (Vectibix) Vemurafenib (Zelboraf)
Exemestane (Aromasin) Pazopanib (Votrient) Vismodegib (Erivedge)
Fulvestrant (Faslodex) Pertuzumab (Perjeta)
Gefitinib (Iressa) Ponatinib (Iclusig)
Crenolanib (CP-868-596) Ganetespib (STA-9090) Retaspimycin (IPI-504)
Dacomitinib (PF-00299804) Neratinib (HKI-272) Rociletinib (CO-1686)
Dinaciclib (SCH-727965) Quizartinib (AC220) Selumetinib (AZD6244)
Dovitinib (TKI258) Refametinib (BAY86-9766) Tanespimycin (17-AAG)

Types of Alterations Detected

SNVs1 Solid Tumor Profiling

SNVs

Fusions Solid Tumor Profiling

Fusions

CNVS2 Solid Tumor Profiling

CNVs

Indels Solid Tumor Profiling

Indels

OncoGxSelect™ Report

Sample Report
OncoGxOne__Plus_Sample_report_thumb Solid Tumor Profiling

OncoGxSelect™ Information Sheet

Information Sheet
OncoGxSelect_Info_sheet_thumb-1 Solid Tumor Profiling